Carbohydrate recognition and complement activation by rat ficolin-B
نویسندگان
چکیده
منابع مشابه
Carbohydrate recognition and complement activation by rat ficolin-B
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L- and H-ficolin) and a leukocyte-associated form (M-ficolin), whereas rodents and most other mammals produce ficolins-A and -B, orthologues of L- and M-ficolin, respectively. All three human ficolins, together with mouse and rat ficolin-A, associate with mannan-binding le...
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Mannose-binding lectin (MBL) and ficolin are complexed with MBL-associated serine proteases, key enzymes of complement activation via the lectin pathway, and act as soluble pattern recognition molecules in the innate immune system. Although numerous reports have revealed the importance of MBL in infectious diseases and autoimmune disorders, the role of ficolin is still unclear. To define the sp...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2010
ISSN: 0014-2980
DOI: 10.1002/eji.201040612